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TadalafilGeneric name:Cialis

PronunciationTadalafil (imiter) or Cialis

Drug class

Tadalafil, Cialis, Levitra, Sinemet, Vardenafil

Pharmacology

Tadalafil belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors and is used to treat erectile dysfunction and benign prostatic hyperplasia. Tadalafil belongs to a class of drugs called tadalafil-type PDE5 inhibitors.

Dosage and Posology

Tadalafil is usually taken orally in the form of a tablet. The recommended dosage of tadalafil is up to 25 mg once daily. Tadalafil is only available by prescription.

Tadalafil should be taken at a dose of one tablet per day. Taking more than the recommended dose in one day may result in dizziness or drowsiness, especially when the effect of the drug is felt.

Tadalafil should be taken at the lowest effective dose (25 mg) for the shortest duration. The dose should not be reduced as rapidly.

For the treatment of pulmonary arterial hypertension (PAH), the recommended dosage is 50 mg once daily or 100 mg once daily. In PAH, the recommended dosage is 20 mg once daily.

Tadalafil may take several weeks to regularly become effective in treating ED and benign prostatic hyperplasia (BPH). If tadalafil does not clear up on its own after 12 weeks, it should be continued in the normal dosage.

If you find that the effect of tadalafil is not working, or if it becomes intolerant of some foods or medicines, you should consult a doctor.

If you are using the sexual stimulation tablets for the first time, take the drug as prescribed by your doctor. You may take the tablet with or without food.

The dosage should be modified based on the patient's age and the severity of erectile dysfunction.

Do not take tadalafil more than once a day.

If you are taking the drug with other medicines, your doctor may suggest you some other treatments based on your response. For example, you may take it with a medicine called retinoid or retinasterandy.

Overdose

In overdose, the symptoms of which are dizziness and drowsiness, there should be no effect in the patient's body. You should immediately contact your doctor and get help if an overdose occurs.

Contraindications

Tadalafil is contraindicated in patients with hypersensitivity (allergy) to any of the ingredients in the drug.

Tadalafil is not recommended for use in patients who have or have had hypersensitivity (angiotensin-converting-en-pin (ACE-in-probe) tests).

Side Effects

The most common side effects of tadalafil are headache, back pain, muscle aches, flushing, dyspepsia, wind, nosebleeds, and urinary retention. These side effects usually last for about 4 to 6 hours after the drug is ingested.

Tadalafil may cause some side effects as per your doctor's instructions. However, you should be aware that side effects of tadalafil may be related to some other drugs or substances (such as blood pressure lowering drugs, fever reducers, and alcohol).

Tadalafil should not be used by men below 18 years of age. Tadalafil should not be used in the treatment of benign prostatic hyperplasia (BPH) in women. In men, tadalafil should be used only if the patient feels the drug is not effective for the treatment of the disease.

Warnings

Do not use tadalafil if:

Do not take tadalafil if:

If you are taking any other PDE5 inhibitor, including any of the following:

Do not use tadalafil in a patient who has taken nitrates or is already taking nitroglycerin.

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Description

Cialis Cialis 20mg contains the active ingredient Tadalafil. Cialis Cialis 20mg is an orally administered treatment for erectile dysfunction (ED). It is the first line of treatment for Erectile Dysfunction. Cialis Cialis 20mg is used to treat erectile dysfunction (ED). It works by helping to increase blood flow to the penis, facilitating the achievement and maintenance of an erection. It is also used to treat benign prostatic hyperplasia (BPH). It is the only ED treatment that does not require ED medication. Cialis Cialis 20mg is not for daily use, and can only be taken once a day. Cialis Cialis 20mg is only for men under 18 years old.

Uses of Cialis Cialis 20mg

Cialis Cialis 20mg is used to treat erectile dysfunction (ED) in men. It also helps to relieve symptoms of benign prostatic hyperplasia (BPH) in men. The medicine contains Tadalafil which belongs to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. PDE5 inhibitors work by blocking the action of an enzyme called phosphodiesterase type 5 (PDE5), which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis. By blocking PDE5, Cialis Cialis 20mg helps to relax the muscles in the blood vessels of the penis and increase blood flow. This helps achieve and maintain an erection when sexually stimulated. It is important to note that Cialis Cialis 20mg does not cure erectile dysfunction, but rather helps to treat ED by increasing blood flow to the penis.

How to use Cialis Cialis 20mg

Before you take Cialis Cialis 20mg, inform your doctor if you suffer from any of the following health problems: heart disease, low or high blood pressure, severe liver or kidney disease, a history of stroke or heart attack or if you have ever had a heart attack, irregular heart rhythm, or have a history of bleeding disorders.

Tell your doctor if you have any of the following health problems: a history of blood clots, stroke, diabetes, kidney disease, or heart disease.

  • Liver or kidney disease
  • Diabetes
  • High or low blood pressure
  • Sickle cell disease or multiple myeloma
  • Bleeding disorders
  • Severe heart failure or angina

Side effects of Cialis Cialis 20mg

Like all medicines, Cialis Cialis 20mg can cause side effects in some people. Common side effects of Cialis Cialis 20mg may include headache, flushing, indigestion, back pain, muscle aches, muscle aches that you may have after eating, or stuffy or runny nose. If you experience any severe side effects or any side effects not mentioned in the product information leaflet, contact your doctor.

Interactions of Cialis Cialis 20mg

Cialis Cialis 20mg may interact with other medicines. Some medicines, including nitrates and certain antibiotics, can increase the blood pressure when taken with Cialis Cialis 20mg. Tell your doctor about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not start or stop taking Cialis Cialis 20mg without talking to your doctor first. Cialis Cialis 20mg is not intended for use in women and children. It is not known if Cialis Cialis 20mg is safe for use in men. Cialis Cialis 20mg is not recommended for use during pregnancy, particularly in the second or third trimester.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Ricanourced & U. S. national institute of research; the results of the study may be available on the institute's nhs website.
  • Other Drug-Food interactions:
  • Cigarette smoking may altering the effectiveness of tadalafil, increasing the risk of side effects.
  • C. Drug-Food interactions:

    Ex.